Fig. 1
From: Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
Changes in microglial cell morphology and accumulation of lipid bodies following treatment with LPS, DHA, or a combination of LPS and DHA. a In the control condition, microglial cell showing a typical morphology charactrized by few filopodia (arrowhead), lipid vacuoles (v), and droplets (asterisk). g Golgi apparatus, er endoplasmic reticulum, m mitochondria. Vacuoles are recognized by their irregular contours and heterogeneous contents. Droplets are characterized by the roundness of their profiles and uniformity of their contents. b Microglial cell in the LPS condition with numerous filopodia and lipid vacuoles but only a few droplets. A phagocytic inclusion (in) identified as an accumulation of partially digested membranes can also be seen. c Microglial cell exposed to DHA showing several filopodial extensions and an increased prevalence of lipid vacuoles and droplets compared with microglial cell in the control and LPS conditions. In the presence of DHA, lipid droplets with an electron-lucent (clear) or electron-dense (dark) content and grouped one to another are observed and become the most prevalent form of lipidic inclusion in the combined presence of LPS and DHA (d)