Fig. 7

Effects of FK506 treatment on behavior in non-tg and gp120 tg mice. Four behaviors were evaluated in the open field test: total activity, total distance, thigmotaxis, and rearing. a Vehicle-treated gp120 tg mice were hyperactive compared to non-tg mice, and FK506 treatment significantly reduced the activity levels compared to vehicle-treated gp120 tg mice. b Vehicle-treated gp120 tg mice covered a significantly greater total distance compared to vehicle-treated non-tg mice. c Thigmotaxis and d rearing were not significantly different between mouse type or treatment group. Scale bar = 10 μm. *p < 0.05, by one-way ANOVA post hoc Dunnett’s. N = 10; age = 12 months of age