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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice

Fig. 2

The levels of TNF-α in the spinal cord and serum of the inoculated mice. Upper. Certain levels of TNF-α were noted in the spinal cord of the mice in group 0 and in control group. However, the level of TNF-α in the spinal cord of the mice injected ip with 10 mg of the IgG from the ALS patient (ALS group) was significantly higher than in the mice inoculated with the IgG from the human normal and disease controls (control group), and in the mice inoculated with the vehicle (without IgG) or with preimmune goat IgG (group 0). The level of TNF-α in the spinal cord of the mice inoculated ip with the IgG from the goats immunized with the homogenate of the ventral horn of the bovine spinal cord (goat group) was significantly higher than in the other three groups. The significance of the differences is indicated by the horizontal lines. Lower. No TNF-α was detected in the serum of the animals in group 0, control group, or ALS group, while the serum of the mice in the goat group contained a high level of TNF-α. The data indicate that the IgG from ALS patients raised the level of TNF-α only in the spinal cord of the injected mice. In every figure, the columns denote means and the error bars the SD

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