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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice

Fig. 3

The levels of IL-6 in the spinal cord and the serum of the inoculated mice. Upper. There were demonstrable levels of IL-6 in the spinal cord in group 0 and in control group. The average level of IL-6 was higher in the spinal cord of the mice inoculated ip with 10 mg of ALS IgG, but the difference was not statistically significant. The average level of IL-6 was statistically significantly elevated in the mice in the goat group (inoculated with IgG from the serum of the immunized goats). Lower. Mouse IL-6 was not detected in the serum of the mice in group 0 (injected with only vehicle or preimmune goat serum), and only traces of IL-6 were found in the serum of the mice treated with normal human or disease control IgG (control group). The treatment with human ALS IgG (ALS group) or with IgG from the immunized goats raised the IL-6 level extremely in the serum of the inoculated mice

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Journal of Neuroinflammation

ISSN: 1742-2094