Fig. 1
AMD3100 decrease microglial inflammatory markers and proinflammatory markers. SOD1G93A and LM mice were treated with AMD3100 or PBS and sacrificed at 110 days old, and the levels of activated microglia markers were measured. Five mice in each treatment group of SOD1G93A and LM mice were tested. a TNF-α level in spinal cord homogenates of SOD1G93A mice were measured using ELISA kit. (TNF-α for PBS is 43.77 pg/ml, for AMD3100 is 15.45 pg/ml) b IL-6 levels of SOD1G93A mice measured via western blot analysis. c Iba-1 levels of SOD1G93A mice measured via western blot analysis. d Immunohistochemical staining of Iba-1. e cd36 levels of SOD1G93A mice measured via western blot analysis. Results are mean ± S.E.M., *p < 0.05, **p < 0.01