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Table 1 Peripheral inflammation increases flux through the kynurenine pathway of tryptophan metabolism

From: Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Metabolite Concentration (μM) t test
Saline 24 h LPS p value
Tryptophan 94.93 (7.1) 119.53 (3.9) p < 0.01
Kynurenine 0.83 (0.08) 2.40 (0.2) p < 0.001
3-Hydroxykynurenine (3-HK) 0.16 (0.02) 0.27 (0.04) p < 0.001
3-Hydroxyanthranilic acid (3-HAA) 3.99 (0.3) 4.87 (0.4) n.s.
Quinolinic acid (QA) 0.98 (0.06) 0.97 (0.07) n.s.
Kynurenic acid (KA) 0.24 (0.03) 0.27 (0.01) n.s.
Kynurenine/tryptophan ratio 0.0092 (0.0004) 0.020 (0.005) p < 0.001
3-HK/KA ratio 0.55 (0.04) 1.08 (0.07) p < 0.001
  1. Kynurenine pathway metabolites (μM) were assessed by LC/MS in the plasma 24 h following saline or LPS treatment. Metabolites measured include tryptophan, kynurenine, 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), quinolinic acid (QA), and kynurenic acid (KA). Kynurenine/tryptophan and 3-HK/KA ratios were calculated. Data represent sample means (SEM) and were analyzed using a t test (results denoted in table). n = 7–12 samples/group, n.s. not significant