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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

Fig. 5

IL4 gene therapy upregulates CD206 in CNS-infiltrating macrophages of EAE mice. Immunofluorescence spinal cord sections of C57Bl/6 mice affected by EAE and treated, at 12 d.p.i, with the GFP-expressing (GFP, a) or the IL4-expressing lentivirus (IL4, b). The staining (CD206 in green, Iba1 in red, nuclei in blue, as indicated) highlights upregulation of CD206 in Iba1+ macrophages in EAE mice treated with IL4 gene therapy (b) as compared to mice treated with the GFP-expressing control virus (a). a, b ×40, scale bar 10 μm. Scale quantification of CD206+ macrophages in spinal cords is shown (± standard deviation) in (c). *P < 0.05 (t test)

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