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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

Fig. 6

CNS IL4 gene therapy inhibits clinical and pathological signs of EAE. Clinical course of EAE mice intracisternally injected with the IL4-expressing (IL4, open dots) or the GFP-expressing (GFP, closed dots) lentivirus is shown either as median (a) or mean (±standard deviation) (b) values (EAE score is non-parametric). Arrows indicate the day of virus injection (day 12 post immunization). IL4-treated EAE mice are protected both in terms of clinical severity (including cumulative and maximum score, ad), and demyelination (g) and axonal loss (h). The protective effect of IL4 gene therapy is associated to an increased number of infiltrating CD3+ T cells (e), but no modulation of IB4+ myeloid cells (f). ***P < 0.0001 (Mann–Whitney in a, t test in g); *P < 0.05 (Mann–Whitney in c, d, t test in e)

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