Fig. 3
Activation of PPARγ attenuates enhanced Aβ neurotoxicity by seipin deficiency. a Representative images of the hippocampal CA1 regions (5-μm sections stained with toluidine blue) in WT mice (WT), Aβ25–35 mice (Aβ), seipin-KO mice (KO), Aβ25–35-KO mice (KO/Aβ), rosi-treated Aβ25–35-KO mice (KO/Aβ/rosi), GW9662-treated seipin-KO mice (KO/GW), and KO/Aβ/rosi mice (KO/Aβ/rosi/GW). PcL pyramidal cell layer, OL oriens layer. Scale bars = 50 μm. The bar graph represents the stereological counts of the surviving pyramidal cells. **P < 0.01 vs. WT mice; # P < 0.05 vs. Aβ25–35-KO mice; + P < 0.05 vs. KO/Aβ/rosi mice (three-way ANOVA with Bonferroni’s test). b Representative images of Hoechst staining in the hippocampal CA1 regions. The white arrows indicate the Hoechst+ cells. PcL: pyramidal cell layer; RL: radiatum layer. Scale bars = 50 μm. The bars indicate the density of Hoechst+ cells. **P < 0.01 vs. WT mice; ## P < 0.01 vs. Aβ25–35-KO mice; ++ P < 0.01 vs. KO/Aβ/rosi mice (three-way ANOVA with Bonferroni’s test)