Fig. 5
Activation of PPARγ depresses enhanced GSK3β activity by seipin deficiency. a–c Levels of hippocampal Tyr216 phospho-GSK3β, Ser9 phospho-GSK3β, and phospho-STAT3 in WT mice (WT), Aβ25–35 mice (Aβ), seipin-KO mice (KO), Aβ25–35-KO mice (KO/Aβ), and rosi-treated Aβ mice and KO/Aβ mice. Levels of Tyr216 phospho-GSK3β and Ser9 phospho-GSK3β were first normalized to the amount of GSK3β protein and subsequently normalized to the basal values in WT mice. **P < 0.01 vs. WT mice; ## P < 0.01 vs. Aβ25–35-KO mice (three-way ANOVA). The levels of phospho-STAT3 were normalized to the amount of STAT3 protein and subsequently normalized to the basal values in WT mice. **P < 0.01 vs. WT mice; # P < 0.05 vs. Aβ25–35-KO mice (three-way ANOVA with Bonferroni’s test)