Table 6 Weighted logistic regression analyses to investigate the relationship between microglia and Alzheimer’s pathology in participants with and without dementia
From: Microglial immunophenotype in dementia with Alzheimer’s pathology
Microglia (load (%)) | Meningeal CAA | Parenchymal CAA | Diffuse plaques | Neuritic plaques | Tangles |
|---|---|---|---|---|---|
A. No dementia | |||||
Iba1 | 0.92 (0.84; 1.01) | 0.72 (0.65; 0.79) | 1.2 (1.15; 1.25) | 1.07 (1.02; 1.13) | 0.74 (0.68; 0.80) |
0.064 | <0.001 | <0.001 | 0.003 | <0.001 | |
CD68 | 0.09 (0.01; 0.99) | 0.00 (0.00; 0.01) | 8.62 (3.83; 19.40) | 0.02 (0.01; 0.07) | 1.07 (0.06; 19.41) |
0.049 | <0.001 | <0.001 | <0.001 | 0.965 | |
HLA-DR | 0.27 (0.16; 0.47) | 0.79 (0.56; 1.12) | 2.24 (1.77; 2.83) | 1.02 (0.91; 1.15) | 0.07 (0.02; 0.25) |
<0.001 | 0.183 | <0.001 | 0.728 | <0.001 | |
MSR-A | 0.16 (0.05; 0.47) | 0.03 (0.00; 0.35) | 1.42 (0.95; 2.13) | 0.24 (0.14; 0.40) | 0.44 (0.10; 1.96) |
0.001 | 0.005 | 0.09 | <0.001 | 0.283 | |
CD64 | 1.14 (0.77; 1.69) | 0.70 (0.52; 0.94) | 1.86 (1.57; 2.20) | 0.70 (0.58; 0.86) | 0.77 (0.45; 1.32) |
0.505 | 0.018 | <0.001 | 0.001 | 0.343 | |
B. Dementia with Alzheimer’s pathology | |||||
Iba1 | 1.36 (1.28; 1.45) | 1.53 (1.43; 1.64) | 1.37 (1.24; 1.51) | 1.5 (1.40; 1.61) | 1.14 (1.07; 1.21) |
<0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
CD68 | 1.07 (0.42; 2.73) | 1.40 (0.43; 4.55) | 0.17 (0.06; 0.48) | 31.65 (11.54; 86.81) | 49.28 (19.43; 124.99) |
0.892 | 0.576 | 0.001 | <0.001 | <0.001 | |
HLA-DR | 0.62 (0.52; 0.74) | 1.07 (0.94; 1.22) | 3.22 (2.50; 4.15) | 2.28 (1.65; 3.14) | 1.74 (1.42; 2.13) |
<0.001 | 0.302 | <0.001 | <0.001 | <0.001 | |
MSR-A | 2.43 (1.26; 4.66) | 2.24 (1.03; 4.84) | 2.44 (1.15; 5.21) | 10.31 (5.03; 21.11) | 3.24 (1.74; 6.04) |
0.008 | 0.041 | 0.021 | <0.001 | <0.001 | |
CD64 | 2.15 (1.71; 2.71) | 2.14 (1.63; 2.80) | 21.59 (14.22; 32.78) | 4.39 (3.39; 5.70) | 1.27 (0.99; 1.62) |
<0.001 | <0.001 | <0.001 | <0.001 | 0.056 | |