Fig. 4

AS brain infusion to hmSOD1 mice shortly before the onset of motor neuron dysfunction delayed development of the disease. Fifteen-week-old hmSOD1 mice were brain infused with 10 μg/day AS or the corresponding sense during 6 weeks (n = 12 in each group). AS brain infusion prolonged survival (a), delayed loss of motor function analyzed by Rotarod (b), and delayed neurological score analyzed by a ladder (c). *p < 0.001—significance from sense-treated hmSOD1 mice