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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Fig. 6

WGCNA-clustered gene modules and their correlation to CBD effect in MOG35-55-stimulated TMOG cells. WGCNA analysis identifies distinct modules of coexpressed genes. a Dendrogram showing topological overlap of genes and their relation to modules which are color-coded below. b clustering of resulting modules. Color frames indicate the main modules that are positively (red frame) and negatively (green frame) correlated to CBD effect in MOG35-55-stimulated TMOG. c module-trait relationship plots showing Spearman’s correlation between module principal components (a.k.a. module eigengenes [ME]; in color-coded rows) and the treatments. The top value in each square represents the correlation coefficient between the ME and the treatment. The bottom value in parentheses is the relevant p value. Modules highly correlated with CBD+MOG35-55 treatment are emphasized using black frames

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