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Table 1 List of transcripts which expression is upregulated by MOG35-55 stimulation and this upregulation is suppressed by CBD (p < 0.005)

From: Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Symbol

Gene name

Accession number

MOG alone [fold]$

MOG+CBD [fold]$

Change [%]

CBD alone [fold]$

Cytokines, chemokines, and receptors

 Xcl1

Chemokine (C motif) ligand 1

NM_008510.1

30.0

15.3

−49 %

1.0

 Il3

Interleukin 3

NM_010556.2

25.4

7.2

−72 %

1.0

 Cxcl9

Chemokine (C-X-C motif) ligand 9

NM_008599

7.4

5.4

−27 %

0.9

 Gpr83

G protein-coupled receptor 83

NM_010287

3.9

1.8

−53 %

0.9

 Il12a

Interleukin 12A

NM_008351

2.3

1.5

−24 %

0.9

 Cxcr1

Chemokine (C-X-C motif) receptor 1 (Il8ra, CD181)

NM_178241.1

1.7

0.9

−50 %

0.7

 Il1b

Interleukin 1, beta

NM_008361

1.5

0.5

−70 %

0.3

 Ifngr1

Interferon gamma receptor 1

NM_10511.1

0.8

0.3

−60 %

0.4

Transcription factors and regulators

 Ier3

Immediate early response 3

NM_133662.1

5.5

3.8

−31 %

1.3

 Atf3

Activating transcription factor 3

NM_007498.2

4.7

3.4

−28 %

1.1

 Nr4a3

Nuclear receptor subfamily 4, group A, member 3

NM_015743.1

4.1

3.2

−22 %

1.0

 Crem

cAMP responsive element modulator

NM_013498

1.9

0.9

−50 %

0.5

TNF-family signaling elements

 Tnfsf11

Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa-B ligand (RANKL))

NM_011613.2

11.8

8.2

−31 %

0.9

 Tnfsf14

Tumor necrosis factor ligand superfamily member 14

NM_019418.1

5.0

3.5

−30 %

1.0

 Tnfrsf9

Tumor necrosis factor receptor superfamily, member 9

NM_011612.2

4.2

3.3

−21 %

0.8

 Tnfrsf18

Tumor necrosis factor receptor superfamily, member 18

NM_009400.1

1.3

0.7

−40 %

0.5

Signaling elements

 Sphk1

Sphingosine kinase

NM_011451

12.3

8.2

−34 %

1.0

 Amica1

Adhesion molecule interacting with CXADR antigen

NM_001005421.2

5.0

3.9

−21 %

1.2

 Axud1

Cysteine/serine-rich nuclear protein 1/TGF-beta induced apoptosis protein 3

NM_153287.2

4.4

3.5

−20 %

0.9

 Cdk5r1

Cyclin-dependent kinase 5 activator 1

NM_009871.2

3.9

3.1

−20 %

0.9

 Igfbp4

Insulin-like growth factor binding protein 4

NM_010517.2

2.3

1.1

−50 %

0.5

 Vps37b

Vacuolar protein sorting 37 homologue B

NM_177876.2

1.5

0.6

−60 %

0.4

 Dgat1

Diacylglycerol O-acyltransferase 1

NM_010046.2

1.0

0.4

−60 %

0.4

 Tubb2d

Tubulin, beta 2b

NM_023716.1

0.8

0.5

−50 %

0.5

 Fdps

Farnesyl diphosphate synthase

NM_134469

0.8

0.4

−50 %

0.5

  1. $The results are presented as fold change vs control (without MOG35-55 or CBD). Numbers in italics indicate a significant effect of CBD alone (p < 0.005) in non-stimulated TMOG