Skip to main content

Advertisement

Table 1 List of transcripts which expression is upregulated by MOG35-55 stimulation and this upregulation is suppressed by CBD (p < 0.005)

From: Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Symbol Gene name Accession number MOG alone [fold]$ MOG+CBD [fold]$ Change [%] CBD alone [fold]$
Cytokines, chemokines, and receptors
 Xcl1 Chemokine (C motif) ligand 1 NM_008510.1 30.0 15.3 −49 % 1.0
 Il3 Interleukin 3 NM_010556.2 25.4 7.2 −72 % 1.0
 Cxcl9 Chemokine (C-X-C motif) ligand 9 NM_008599 7.4 5.4 −27 % 0.9
 Gpr83 G protein-coupled receptor 83 NM_010287 3.9 1.8 −53 % 0.9
 Il12a Interleukin 12A NM_008351 2.3 1.5 −24 % 0.9
 Cxcr1 Chemokine (C-X-C motif) receptor 1 (Il8ra, CD181) NM_178241.1 1.7 0.9 −50 % 0.7
 Il1b Interleukin 1, beta NM_008361 1.5 0.5 −70 % 0.3
 Ifngr1 Interferon gamma receptor 1 NM_10511.1 0.8 0.3 −60 % 0.4
Transcription factors and regulators
 Ier3 Immediate early response 3 NM_133662.1 5.5 3.8 −31 % 1.3
 Atf3 Activating transcription factor 3 NM_007498.2 4.7 3.4 −28 % 1.1
 Nr4a3 Nuclear receptor subfamily 4, group A, member 3 NM_015743.1 4.1 3.2 −22 % 1.0
 Crem cAMP responsive element modulator NM_013498 1.9 0.9 −50 % 0.5
TNF-family signaling elements
 Tnfsf11 Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa-B ligand (RANKL)) NM_011613.2 11.8 8.2 −31 % 0.9
 Tnfsf14 Tumor necrosis factor ligand superfamily member 14 NM_019418.1 5.0 3.5 −30 % 1.0
 Tnfrsf9 Tumor necrosis factor receptor superfamily, member 9 NM_011612.2 4.2 3.3 −21 % 0.8
 Tnfrsf18 Tumor necrosis factor receptor superfamily, member 18 NM_009400.1 1.3 0.7 −40 % 0.5
Signaling elements
 Sphk1 Sphingosine kinase NM_011451 12.3 8.2 −34 % 1.0
 Amica1 Adhesion molecule interacting with CXADR antigen NM_001005421.2 5.0 3.9 −21 % 1.2
 Axud1 Cysteine/serine-rich nuclear protein 1/TGF-beta induced apoptosis protein 3 NM_153287.2 4.4 3.5 −20 % 0.9
 Cdk5r1 Cyclin-dependent kinase 5 activator 1 NM_009871.2 3.9 3.1 −20 % 0.9
 Igfbp4 Insulin-like growth factor binding protein 4 NM_010517.2 2.3 1.1 −50 % 0.5
 Vps37b Vacuolar protein sorting 37 homologue B NM_177876.2 1.5 0.6 −60 % 0.4
 Dgat1 Diacylglycerol O-acyltransferase 1 NM_010046.2 1.0 0.4 −60 % 0.4
 Tubb2d Tubulin, beta 2b NM_023716.1 0.8 0.5 −50 % 0.5
 Fdps Farnesyl diphosphate synthase NM_134469 0.8 0.4 −50 % 0.5
  1. $The results are presented as fold change vs control (without MOG35-55 or CBD). Numbers in italics indicate a significant effect of CBD alone (p < 0.005) in non-stimulated TMOG