Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Table 2 List of transcripts which expression is upregulated by MOG35-55 stimulation and not affected by CBD

Symbol	Gene name	Accession number	MOG alone [fold]^$	MOG+CBD [fold]^$	CBD alone [fold]^$
Cytokines
Csf2	Colony stimulating factor 2	NM_009969.2	77.0	67.1	1.1
Tnf	Tumor necrosis factor alpha	NM_013693.1	15.3	13.8	1.1
Ifng	Interferon gamma	NM_008337.1	10.8	9.5	0.8
Chemokines
Ccl3	Chemokine (C-C motif) ligand 3	NM_011337.1	54.1	48.6	0.9
Ccl4	Chemokine (C-C motif) ligand 4	NM_013652.1	40.2	37.3	0.9
Cxcl10	Chemokine (C-X-C motif) ligand 10	NM_021274.1	9.0	9.8	0.9
Glycoproteins
Sema7a	Semaphorin 7A (GPI membrane anchor)	NM_011352.2	4.6	4.3	0.8
Transcription factors
Egr2	Early growth response 2	NM_010118.1	20.1	18.9	1.3
Egr1	Early growth response 1	NM_007913.2	10.7	11.7	1.5
Tbx21	T-box 21	NM_019507.1	2.2	2.5	0.9
Signaling elements
Ndrg1	N-myc downstream regulated 1	NM_010884.1	6.2	6.7	2.5
Ifit3	Interferon-induced protein with tetratricopeptide repeats 3	NM_010501.1	5.6	5.9	0.9

^$The results are presented as fold change vs control (without MOG35-55 or CBD). Numbers in italics indicate a significant effect of CBD alone (p < 0.005)

ISSN: 1742-2094