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Table 3 List of genes which transcription is enhanced by CBD in TMOG cells (p < 0.005)

From: Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Symbol Gene name Accession number MOG alone [fold]$ MOG+CBD [fold]$ Change [%] CBD alone [fold]$
MOG35-55-upregulated and CBD-enhanced
Surface negative regulators
 Lag3& Lymphocyte-activation gene 3 NM_008479.1 1.7 5.2 +210 % 1.7
 Btla B and T lymphocyte associated NM_177584.3 1.8 3.2 +80 % 2
 Cd69 Cluster of Differentiation 69 XM_132882.1 3.9 5.4 +39 % 1.4
IFN-dependent transcripts
 Rsad2 Radical S-adenosyl methionine domain containing 2 NM_021384.2 4.9 9.5 +94 % 1.6
 Trim30 Tripartite motif-containing 30 NM_009099 2.2 3.1 +40 % 1.1
 Mx2 Myxovirus (influenza virus) resistance 2 NM_013606 6.0 8.2 +37 % 1.0
 Irf4 Interferon regulatory factor 4 NM_013674.1 4.5 5.3 +18 % 1.4
Signaling elements
 Gbp11 Guanylate binding protein 11 NM_01039647.1 3.2 7 +120 % 1.1
 Ppic Peptidylprolyl isomerase C NM_008908.1 1.8 3.2 +80 % 1.8
 Tyki Thymidylate kinase family LPS-inducible member NM_020557.3 4 5.7 +42 % 1
 Tagap T-cell activation RhoGTPase activating protein NM_145968.1 4.7 6.4 +35 % 1.4
 Tnfsf8 Tumor necrosis factor (ligand) superfamily, member 8 NM_009403.2 2.2 2.9 +31 % 1.1
 Dusp6 Dual specificity phosphatase 6 NM_026268.1 3.4 4.3 +26 % 1.4
 Gfod1 Glucose-fructose oxidoreductase domain containing 1 NM_001033399.1 6.2 7.8 +26 % 1.0
 Nfatc1& Nuclear factor of activated T-cells, cytoplasmic 1 NM_16791 3.3 4 +21 % 1.3
Only CBD upregulated
Anti-oxidant and anti-inflammatory
 Mt1 Metallothionein 1 NM_013602.2 0.5 2.3 +330 % 3
 Slc30a1 Solute carrier family 30 (zinc transporter), member 1 NM_009579 0.9 1.8 +100 % 1.8
 Mt2 Metallothionein 2 NM_008630.1 1 1.9 +80 % 2.3
Negative regulators of T cell activity
 Trat1 T cell receptor associated transmembrane adaptor 1 NM_198297 0.7 2.1 +200 % 1.6
IFN-dependent transcripts
 Ephx1 Epoxide hydrolase 1 NM_010145.2 0.7 1.8 +170 % 2.4
 Ets2 V-ets avian erythroblastosis virus NM_011809.2 1.3 2.4 +80 % 1.3
Signaling elements
 Ddr1 Discoidin domain receptor tyrosine kinase 1 NM_007584.1 1.1 3 +170 % 2.4
 Pitpnm2 Phosphatidylinositol transfer protein, membrane-associated 2 NM_011256.1 1.2 2.9 +150 % 2.6
 Gpnmb Glycoprotein (transmembrane) nmb NM_053110.2 0.4 0.9 +90 % 2.2
 Asb2 Ankyrin repeat and SOCS box-containing protein 2 NM_023049.1 0.29 0.52 +79 % 1.38
 Slc3a2 Solute carrier family 3 member 2 NM_008577.2 1.3 2.3 +70 % 1.5
  1. $The results are presented as fold change vs control (without MOG35-55 or CBD). Numbers in italics indicate a significant effect of CBD (p < 0.005) in non-stimulated TMOG. &result reported previously [25]