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Table 5 IPA-identified “top canonical pathways” enriched by CBD treatment in stimulated TMOG cells

From: Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Canonical pathways

Annotated genes

p value

IL-10 signaling

Hmox1, Il1b, Jun, Socs3

0.0039

IL-6 signaling

Il1b, Jun, Socs3, Srf, Vegfa

0.0042

cAMP-mediated signaling

Crem, Fpr2, Gnal, Grm6, Hrh3

0.024

IGF-1 signaling

Igfbp4, Jun, Socs3, Srf

0.015

Fcγ receptor mediated phagocytosis in macrophages and monocytes

Appc3, Hck, Hmox1, Vav3

0.012

Superpathway of cholesterol biosynthesis

Fdps, Sqle

0.016

T helper cell differentiation

CD40, Ifbgr1, Il21

0.042