Fig. 2
From: Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore
Primary hippocampal cultures expressing exogenous P2X7R exhibited nodular structures as outpouchings of the cell cytoplasm from which emanated a highly organized array of what appeared to be vesicles. a Cultures expressing P2X7R stained with microglial marker isolectin GS-IB4 showed nodular structures (arrow head) from which projected “beaded” structures to the outside of the cell (arrows). Inset shows a higher resolution of the “beaded” structures. b, c Examples of activated microglia expressing exogenous P2X7R-EGFP. As can be noted “nodular” outpouchings of the cell are once again evident with fluorescent “beaded” structures outside the cell. Scale bar: as indicated in the figures