Fig. 8From: Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after strokeComparison of MEMRI and IF. T1-weighted image shows the ring- or crescent-shaped enhancement on MEMRI (a, area located in the red dash line), concordant with the GFAP (+) cells observed in the area between the lateral ventricle and ischemic region (b, thick red arrow). The scattered enhancement in the lesion core was concordant with the GFAP (+) cells sparsely located inside the lesion (b, thin red arrow). T2-weighted MR image of the same animal shows the necrotic core (c, left). CD11b (+) immunostaining shows the area where microglia/macrophages mainly localized (c, right), concordant with the T2-weighted MR images. The graph line shows the same changes at later stages after reperfusion (d). Analysis of positive correlation between astrocyte activation and systemic MEMRI enhancement (e, r = 0.8802, P = 0.0489). Analysis of negative correlation between neuronal damage and systemic MEMRI enhancement (f, r = −0.9121, P = 0.0309). Analysis of positive correlation between astrocyte activation and stereotactic MEMRI enhancement (g, r = 0.9970, P = 0.0497). Scale bars = 500 μmBack to article page