Fig. 2From: The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injuryDcR3.Fc treatment reduces cavity formation and increases myelin sparing at the lesion site. Histological evaluation after DcR3.Fc treatment at the sixth week after SCI. a One of the representative results shows that DcR3.Fc-treated and control SCI rats were examined under microscope after H&E staining (scale bar: 250 μm). b Quantified empty space of the total spinal area from two groups to determine the percentage of the cavity area at the epicenter and the rostral to caudal (−1.6 to 1.6 mm, 0 mm indicates the epicenter) after injury. The cavity areas show that DcR3 treatment produced a smaller cavity area at the epicenter and the rostral to caudal (−0.4 to 0.4 mm) of the injury (*p < 0.05, N = 4 in each group). c LFB staining of the transverse spinal cord sections (−2, 0, and 2 mm) in DcR3.Fc-treated and control SCI rats (scale bar: 250 μm). d Quantified volumes of myelin sparing from −2 mm rostral to 2 mm caudal of the epicenter at the lesion site. DcR3.Fc-treated rats have higher tissue volume than control group. (*p < 0.05, DcR3.Fc, N = 4 in each group). The results are presented as means ± SEMBack to article page