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Table 3 Changes in inflammatory mediators

From: Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial

  Treatment (n = 12) Control (n = 8) Two-way ANOVA (p value) Mann-Whitney (p value) Friedman [Treat.] (p value)
  Baseline 1 month 3 months Baseline 1 month 3 months    
Proinflammatory composite (pg/ml) 20.3 ± 34.5 13.1 ± 23.6* 14.6 ± 25.2* 9.8 ± 11.6 15.4 ± 22.3 15.7 ± 25.3 <0.01 0.04
CRP (ng/ml) 4474.7 ± 3578.9 3822.6 ± 3749.4 2865.0 ± 2684.9 2388.1 ± 2928.1 3074.0 ± 3026.4 2458.8 ± 3678.9 0.10 0.10
IL-2 (pg/ml) 21.3 ± 51.2 15.1 ± 41.7 17.2 ± 42.1 1.7 ± 3.4 2.9 ± 3.6 2.3 ± 3.3 <0.01 0.23
IL-6 (pg/ml) 13.9 ± 28.2 9.2 ± 21.3* 9.5 ± 19.3 9.0 ± 10.5 13.8 ± 21.2 13.5 ± 21.9 0.13 0.049
IL-1B (pg/ml) 0.9 ± 1.1 0.3 ± 0.3** 0.3 ± 0.2** 0.3 ± 0.3 0.4 ± 0.5 0.3 ± 0.2 <0.01 <0.01
TNF-α (pg/ml) 12.5 ± 3.6 11.8 ± 5.5 11.2 ± 4.1 9.8 ± 3.9 11.3 ± 6.7 12.9 ± 10.3 0.10
IFN-y (pg/ml) 52.9 ± 94.0 31.9 ± 57.5* 35.0 ± 68.4* 28.1 ± 46.8 48.8 ± 84.6 49.6 ± 95.3 <0.01 0.01
Anti-inflammatory Composite (pg/ml) 15.7 ± 13.7 17.2 ± 15.4 17.3 ± 19.1 28.8 ± 28.3 40.1 ± 44.9 36.3 ± 39.5 0.32 1.0
IL-4 (pg/ml) 7.5 ± 20.8 12.4 ± 23.9 16.2 ± 38.4 19.8 ± 37.2 37.4 ± 83.8 23.8 ± 46.3 0.54 0.63
IL-10 (pg/ml) 6.5 ± 12.9 11.2 ± 29.7 9.3 ± 22.0 5.9 ± 14.4 5.7 ± 13.7 6.3 ± 14.6 0.96 0.50
IL-1RA (pg/ml) 33.1 ± 26.2 27.8 ± 18.6 26.3 ± 16.0 60.6 ± 66.6 77.2 ± 77.2 78.8 ± 105.8 0.88 0.72
PGE2 (pg/ml) 496.5 ± 452.7 636.4 ± 544.9 353.0 ± 357.5 605.1 ± 491.2 605.6 ± 504.6 661.7 ± 503.7 0.07
LTB4 (pg/ml) 127.8 ± 181.8 119.8 ± 194.9 77.0 ± 73.8 121.3 ± 172.3 87.6 ± 59.3 145.1 ± 179.8 0.70 0.78
  1. All results are shown as mean ± SD. p values correspond to group × time interactions, Mann-Whitney change scores, and Friedman scores for treatment group, respectively
  2. Proinflammatory composite consists of a composite score averaging IL-2, IL-6, IL-1B, TNF-α, and IFN-y
  3. Anti-inflammatory composite consists of a composite score averaging IL-4, IL-10, and IL1RA
  4. *Significantly different from baseline with p value <0.05
  5. **Significantly different from baseline with p value <0.01
  6. Note: Adapted from “Targeting inflammation to influence mood following spinal cord injury: A randomized clinical trial” by David J. Allison and David S. Ditor, 2015, Journal of Neuroinflammation