Table 3 Changes in inflammatory mediators

Proinflammatory composite (pg/ml)

20.3 ± 34.5

13.1 ± 23.6*

14.6 ± 25.2*

9.8 ± 11.6

15.4 ± 22.3

15.7 ± 25.3

–

<0.01

0.04

CRP (ng/ml)

4474.7 ± 3578.9

3822.6 ± 3749.4

2865.0 ± 2684.9

2388.1 ± 2928.1

3074.0 ± 3026.4

2458.8 ± 3678.9

–

0.10

0.10

IL-2 (pg/ml)

21.3 ± 51.2

15.1 ± 41.7

17.2 ± 42.1

1.7 ± 3.4

2.9 ± 3.6

2.3 ± 3.3

–

<0.01

0.23

IL-6 (pg/ml)

13.9 ± 28.2

9.2 ± 21.3*

9.5 ± 19.3

9.0 ± 10.5

13.8 ± 21.2

13.5 ± 21.9

–

0.13

0.049

IL-1B (pg/ml)

0.9 ± 1.1

0.3 ± 0.3**

0.3 ± 0.2**

0.3 ± 0.3

0.4 ± 0.5

0.3 ± 0.2

–

<0.01

<0.01

TNF-α (pg/ml)

12.5 ± 3.6

11.8 ± 5.5

11.2 ± 4.1

9.8 ± 3.9

11.3 ± 6.7

12.9 ± 10.3

0.10

–

–

IFN-y (pg/ml)

52.9 ± 94.0

31.9 ± 57.5*

35.0 ± 68.4*

28.1 ± 46.8

48.8 ± 84.6

49.6 ± 95.3

–

<0.01

0.01

Anti-inflammatory Composite (pg/ml)

15.7 ± 13.7

17.2 ± 15.4

17.3 ± 19.1

28.8 ± 28.3

40.1 ± 44.9

36.3 ± 39.5

–

0.32

1.0

IL-4 (pg/ml)

7.5 ± 20.8

12.4 ± 23.9

16.2 ± 38.4

19.8 ± 37.2

37.4 ± 83.8

23.8 ± 46.3

–

0.54

0.63

IL-10 (pg/ml)

6.5 ± 12.9

11.2 ± 29.7

9.3 ± 22.0

5.9 ± 14.4

5.7 ± 13.7

6.3 ± 14.6

–

0.96

0.50

IL-1RA (pg/ml)

33.1 ± 26.2

27.8 ± 18.6

26.3 ± 16.0

60.6 ± 66.6

77.2 ± 77.2

78.8 ± 105.8

–

0.88

0.72

PGE2 (pg/ml)

496.5 ± 452.7

636.4 ± 544.9

353.0 ± 357.5

605.1 ± 491.2

605.6 ± 504.6

661.7 ± 503.7

0.07

–

–

LTB4 (pg/ml)

127.8 ± 181.8

119.8 ± 194.9

77.0 ± 73.8

121.3 ± 172.3

87.6 ± 59.3

145.1 ± 179.8

–

0.70

0.78