Fig. 3

Typical discharge patterns of A1 cortical neurons from control, cuprizone, 7 days remyelination, and 25 days remyelination mice induced by intracellular injection of square positive current pulses (120 ms; 100 pA). a Representative traces of the discharge patterns induced at resting membrane potentials of −52 mV in different mice groups and a diagram of the thalamocortical slice, indicating recording site for intracellular recordings. b Group of bars represents the mean ± S.E.M. of the interspike intervals (between the first and the second APs) between different mouse groups. Note that the neurons from cuprizone-treated animals exhibited longer interspike intervals compared to control and 7 days remyelination mice. *P < 0.001