Table 1 Characteristics of membrane potential alteration in the primary auditory cortex in control, cuprizone, 7 days remyelination, and 25 days remyelination mouse groups

Experimental groups

RMP (mV)

THP (mV)

APs_amp (mV)

APs_dur (ms)

AHP_amp (mV)

AHP_dur (ms)

APs frequency/s

CTRL (n = 17)

−52.5 ± 0.4

5.4 ± 0.2

60.9 ± 0.8

8.8 ± 0.4

7.1 ± 0.2

94.8 ± 5

9.5 ± 2.3

Cuprizone (n = 11)

−56.1 ± 0.8

4.6 ± 0.1

57.1 ± 0.6

7.9 ± 0.4

5.9 ± 0.2

56.1 ± 3.4

8.14 ± 2

7 days remyelination (n = 18)

−51.01 ± 0.1

4.5 ± 0.1

66.3 ± 0.4

7 ± 0.2

6.5 ± 0.1

65.3 ± 3.2

6.5 ± 2.7

25 days remyelination (n = 16)

−54.7 ± 0.4

4.1 ± 0.1

64.5 ± 1

6.4 ± 0.2

7.4 ± 0.2

96.9 ± 4.1

6.2 ± 1.1

THP (mV)

APs_amp (mV)

APs_dur (ms)

AHP_amp (mV)

AHP_dur (ms)

5.4 ± 0.3

63.1 ± 1.1

8.9 ± 0.6

6.9 ± 0.3

158.9 ± 13.6

3.9 ± 1.2

61.6 ± 0.3

9.9 ± 1.3

5.6 ± 0.3

65 ± 5.2

4.2 ± 0.2

65.6 ± 1.6

6.5 ± 0.6

4.6 ± 0.4

95.4 ± 10

4.6 ± 0.3

64.5 ± 3.8

8.5 ± 0.7

9.1 ± 0.4

139.4 ± 13.7

THP (mV)

APs_amp (mV)

APs_dur (ms)

AHP_amp (mV)

AHP_dur (ms)

4.5 ± 0.2

55.6 ± 1.2

6.6 ± 0.8

7.7 ± 0.2

94.4 ± 7.6

4.1 ± 0.2

45.6 ± 2.1

6.9 ± 0.4

6.8 ± 0.3

54.1 ± 6.1

4.5 ± 0.1

53.6 ± 0.7

7.3 ± 0.3

6.3 ± 0.2

60.5 ± 4

4.4 ± 0.3

51.2 ± 1.3

8.9 ± 0.4

8.6 ± 0.2

93.7 ± 7

IPSP_amp

IPSP_dur

EPSP_amp

EPSP_dur

7.8 ± 0.6

92 ± 6

6.8 ± 0.5

47.5 ± 4.1

8.2 ± 0.3

122.9 ± 11.7

2.8 ± 0.2

91.6 ± 11.9

9.8 ± 1.2

147 ± 30

6.5 ± 0.4

98.3 ± 12.7

8.5 ± 0.5

92.4 ± 6

7.1 ± 0.4

178.5 ± 18.4