Fig. 2

Post-injury administration of pomalidomide (Pom: 0.5 mg/kg, i.v.) at 5 h after TBI significantly reduced contusion volume evaluated at 24 h. A lower Pom dose (0.1 mg/kg i.v.) and longer time window (7 h) reduced efficacy. a Representative cresyl violet stained coronal brain sections of the CCI TBI-induced cavity in Sham (control without TBI), TBI-vehicle (TBI + veh), and pomalidomide-treated TBI rats (TBI + Pom) at 24 h post-TBI. b The TBI-induced contusion volume evaluated at 24 h was significantly reduced by Pom (0.5 mg/kg), but not by Pom (0.1 mg/kg) treatment. c Post-injury administration of Pom (0.5 mg/kg) at 5 h, but not at 7 h, significantly reduced the contusion volume relative to TBI + vehicle (TBI + veh) group. Data are expressed as mean ± S.E.M. (n = 5 in each group). *p < 0.05, **p < 0.01, ***p < 0.001 compared with the sham group. ^## p < 0.01 compared with the TBI + veh group