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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?

Fig. 1

Scheme summarizing some known and some hypothetical functions of MT5-MMP in nervous system pathophysiology. Solid lines/frames represent biological actions and functional interactions reported in the literature. Dotted lines/insets represent the alternative/complementary hypotheses we propose herein. APP: amyloid precursor protein; ABP: AMPA receptor binding protein; CNS: central nervous system; GRIP: glutamate receptor interacting protein; IL-1β: interleukin-1 beta; PNS: peripheral nervous system; TNF-α: tumor necrosis factor-alpha

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