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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies

Fig. 2

Free NAT, cell-bound NAT and VLA 4 expression levels in patients subjected to extended treatment intervals and after cessation of therapy. Free NAT concentration (a), cell-bound NAT on CD3 cells (b) and VLA-4 expression in CD3 cells (c) in blood after cessation of NAT treatment (NAT; black circle) compared with that in untreated patients with MS (non-NAT; black triangle). Values were determined 20 min after the last NAT infusion, at baseline, and for different patients during the subsequent 16 weeks. Free NAT concentration in CSF after cessation of NAT therapy (d). Free NAT concentrations of patients receiving 4- (black circle), 5- (black square) and 8-week (black triangle) intervals between treatments (e). Free NAT concentration in CSF of patients receiving 4- (black circle) and 5-weeks (black square) intervals between treatments (f). Blood values were determined before (NAT Pre) and 20 min after (NAT Post) NAT infusion. *p < 0.1, **p < 0.01, ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094