Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture

Table 2 Logistic regression models of factors associated with delirium at any time

	Unadjusted models			Adjusted model
	OR	95 % CI	p value	OR	95 % CI	p value
Age (years)	1.07	1.02 to 1.11	0.004
IQCODE	4.56	2.43 to 8.52	<0.001	5.81	2.77 to 12.21	0.001
APACHE II score	1.11	0.96 to 1.27	0.15
Independent in ADL	0.24	0.12 to 0.49	<0.001
Time from admission to surgery, hours	1.02	1.00 to 1.05	0.046	1.04	1.01 to 1.07	0.017
Living in an institution	4.61	1.80 to 11.76	0.001
CSF Neopterin, nmol/L^a	3.67	1.58 to 8.47	0.002	3.31	1.24 to 8.86	0.017
Centre (reference: Oslo)	0.59	0.30 to 1.19	0.14	0.58	0.22 to 1.52	0.27

n = 127 in the regression analyses, some patients had to be excluded due to missing data. Variables associated with delirium in univariate analysis (p < 0.1) were considered for inclusion in the multivariate model, and variables were removed one by one by backwards stepping until the final model was reached. Centre (Oslo or Edinburgh) was, however, forced into the final model
IQCODE informant questionnaire on cognitive decline in the elderly, APACHE II Acute Physiology and Chronic Health Evaluation II, ADL activities of daily living, CSF cerebrospinal fluid
^aCSF neopterin dichotomized at the 75th percentile

ISSN: 1742-2094