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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

Fig. 4

Effects of histidine on PSL-induced activation of spinal microglia. Photomicrographs show Iba-1 labeling in the lumbar spinal cord on day 1 (a–c), day 3 (e–g), and day 7 PO (i–l). Insets are high-magnification images to demonstrate multidimensional changes of spinal microglia in the ipsilateral spinal dorsal horn. d, h, and m represent the quantitative analysis of the area occupied by Iba-1-positive cells on day 1, day 3, and day 7 PO, respectively. Histidine (100 mg/kg, i.p.) administered once daily during the period of 0–1, 2–3, 0–3, and 0–7 days PO reduced Iba-1 expression following PSL. Scale bar = 200 μm (top) and 20 μm (insets). **P < 0.01, ***P < 0.001, compared with the saline-treated group. $ P < 0.05, compared with the indicated groups. n = 3–4/per group

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