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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

Fig. 7

Histidine reduced IL-1β upregulation in the spinal cord induced by PSL. Histidine (100 mg/kg, i.p.) administered once daily during the period of 0–1, 2–3, 0–3, and 0–7, but not 4–7 days PO, reduced the increase in levels of IL-1β (a, b). Histidine (100 mg/kg, i.p.) did not show any analgesic effect if IL-1β (10 ng, i.t.) was administered 2 h later (c, d) in 3 days PO. Histidine (200 mg/kg, i.p.) administered through 0–7 days PO did not affect hypersensitivity and microglial activation following PSL in IL-1R−/− mice (eh). Scale bar = 200 μm (bottom) and 20 μm (insets). *P < 0.05, **P < 0.01, and *** P < 0.001 compared with the indicated groups. # P < 0.05, ## P < 0.01, and ### P < 0.001, compared with the baseline. $ P < 0.05 and $$ P < 0.01, compared with the indicated groups. n = 7–9/group

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