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Table 1 Histamine concentrations in the medulla and lumbar cord of rats following intraperitoneal injection of histidine (100 mg/kg) once daily for 3 days

From: A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

Groups Medulla (ng/g) Lumbar cord (ng/g)
Saline Not detectable 20 ± 28
Histidine 100 mg/kg i.p. 120 ± 69** 165 ± 90*
  1. *P < 0.05 and **P < 0.01 (the concentration in the medulla of saline-treated group was designated 10 ng/g, the minimum detectable concentration for our HPLC method, arbitrarily for comparison between the groups)