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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease

Fig. 5

Alterations in MHC-related genes and MHCI protein induced by long-term THP treatment. a Confocal analysis of THP-treated aging brains revealed decreased MHCI-positive cells. Scale bar = 50 μm. b qRT-PCR revealed mRNA encoding MHC genes (H2-Ea, MR1, Cd74, RT1-CE12), and COL1a2 is significantly downregulated by THP in the hippocampus (mean ± SD, n = 3). *P < 0.05, **P < 0.01 compared with the younger group (3 months old); &P < 0.05, &&P < 0.05 compared with the NS-treated aging group (Dunnett’s test)

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Journal of Neuroinflammation

ISSN: 1742-2094