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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease

Fig. 8

Qualitative profile of activated microglia in the rat brain after long-term THP treatment. a and b show IBa1 and CD11b expression in the cortex and hippocampus, respectively. In animals following long-term THP treatment, microglia increased in number (IBa1) and became activated (CD11b), with altered morphology and upregulated CD11b. Scale bar = 50 μm. c, d Activated microglia were quantified by Western blot analysis of cortical CD11b and CD68 expression. &P < 0.05, &&&P < 0.0001 compared with the NS-treated group (Dunnett’s test)

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Journal of Neuroinflammation

ISSN: 1742-2094