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Table 2 List of the top five cellular components related to different gene expression between the THP-treated and NS-treated aging rat index by the GO cellular component term

From: Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease

GO term

Count

Protein

p value

q value

MHCI complex (MHCI)

23

RT1-Aw2; RT1-149; ENSRNOP00000047071; Q6MG05_RAT; RT1-CE10; ENSRNOP00000057803; Q6MG34_RAT; Q861Q3_RAT; ENSRNOP00000041900; Q6MGB8_RAT; ENSRNOP00000047152; Q6MGB9_RAT; Q6MG28_RAT; RT1-Cl; RT1-CE14; Q9JHM2_RAT; RT1-Aw2; XP_001070321; Q6MG29_RAT; Rt1.aa; XP_001072758; Q6MG32_RAT; Q861Q4_RAT; XP_001052972

1.04E−37

1.28E−35

Extracellular region

40

Mgp; Igf2; Anxa2; Bgn; Lgals1; Igfbp2; Fmod; Lum; Ptgds; Penk; Dpp4; Oxt; Gdf10; Cartpt; Tac1; Col1a2; Fn1; DEF3B_RAT; Q6MG90_RAT; C4; Col3a1; Nid1; Rbp4; Serping1; Aebp1; ENSRNOP00000046622; Frzb; Cbln1; Kazald1; Klk8; Omd; Avp; Col1a2; Cklf; Cklf; Bmp6; Ccl6; Bmp7; Timp3; Cxcl13; Nts; Chrdl1

1.22E−33

5.09E−32

Extracellular space

20

Lgals1; Ptgds; Lcat; Oxt; Cp; Cp; Cp; Gdf10; Cartpt; Ada; Col1a2; DEF3B_RAT; Q6MG90_RAT; C4; Rbp4; Serping1; Klk8; Lpl; Col1a2; Cklf; Cklf; Bmp6; Ccl6; Bmp7

1.15E−23

2.81E−22

Myosin

14

Myh11; ENSRNOP00000047484; XP_001053321; XP_001053402; XP_001053536; XP_001073030; XP_001072354; XP_001078110; XP_001076239; XP_576790; XP_001072168; XP_576882; XP_001065390

6.34E−21

1.12E−19

Membrane

51

Ptgds; Slc13a3; Dab2; Enpep; Thbd; Trpc4; ENSRNOP00000052645; ENSRNOP00000052642; ENSRNOP00000052641; ENSRNOP00000052640; ENSRNOP00000052638; ENSRNOP00000052636; ENSRNOP00000008172; ENSRNOP00000052635; Ada; Pln; RT1-Da; ENSRNOP00000003349; Colec12; XP_001061172; MGC108823; XP_574157; Thbd; Fmo1; Cklf; Cklf; ENSRNOP00000058354; INIB_RAT; RT1-Aw2; RT1-149; ENSRNOP00000047071; Q6MG05_RAT; RT1-CE10; ENSRNOP00000057803; Q6MG34_RAT; Q861Q3_RAT; ENSRNOP00000041900; Q6MGB8_RAT; ENSRNOP00000047152; Q6MGB9_RAT; Q6MG28_RAT; RT1-Cl; RT1-CE14; Q9JHM2_RAT; RT1-Aw2; XP_001070321; Q6MG29_RAT; Rt1.aa; XP_001072758; Q6MG32_RAT; Q861Q4_RAT; XP_001052972; Clic2; ENSRNOP00000001372

2.89E−14

3.59E−13

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Journal of Neuroinflammation

ISSN: 1742-2094