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Table 2 Antibody binding of 47 AQP4-IgG-positive baseline serum samples to AQP4-M23, AQP4-M1 and AQP4-M23 mutants

From: Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders

 

AQP4-IgG binding ratio (mean, 95 % CI)

AQP4-IgG binding in % of AQP4-M23 (mean, 95 % CI)

AQP4-M23 isoform

4.84 (3.98–5.70)

Reference (100 %)

AQP4-M1 isoform

1.48 (1.11–1.86)

25.83 (20.19–31.47)

AQP4-mycA (loop A)

2.74 (2.17–3.31)

38.15 (28.95–47.35)

AQP4-delA3 (loop A)

2.85 (2.26–3.44)

40.91 (31.99–49.82)

AQP4-mycC (loop C)

1.49 (1.38–1.60)

13.12 (9.34–16.90)

AQP4-N153Q (loop C)

3.88 (3.26–4.50)

67.35 (56.88–77.81)

AQP4-mycE (loop E)

1.17 (1.12–1.23)

5.39 (3.69–7.08)

AQP4-H230G (loop E)

2.69 (2.12–3.25)

36.28 (29.62–42.95)