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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

Fig. 8

A schematic showing of Gas1 functional ways in mediating apoptosis of reactive astrocytes, in which up-regulation of inducible Gas1 signaling might be resulted from inflammatory NFkB activation, and then possibly participate in increasing reactive oxygen species (ROS) or oxidative stress, enhancing Bax/Bcl-2 ratios, and finally triggering caspase-3 activation-related apoptosis of reactive astrocytes in LPS and MPTP models or inflammatory events

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Journal of Neuroinflammation

ISSN: 1742-2094