Fig. 2
RNA-seq analyses reveals LPS-induced inflammatory response-related genes and their downstream effectors in BV2 cell lines and PM. a A heat map representing the top 150 inflammatory genes that were up-regulated by 2- and 4-h LPS stimulation in BV2 cell lines and PM (P ≤ 0.01, and log2 fold change ≥1.5). Each row shows the relative expression level for a single gene, and each column shows the expression level of a single sample. Biological replicates (n = 3) for each condition were performed. b, c Pie chart displaying the number of up or down-regulated genes at 4-h LPS stimulation in BV2 cell lines and PM. d The area of overlap indicates the number of unique or shared up-regulated genes after 4 h of LPS stimulation in BV2 cell lines and PM. e, f Gene ontology analysis of the functional annotations that were associated with the top 150 up-regulated genes at 4 h after LPS stimulation in the BV2 cell lines and PM