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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease

Fig. 5

Localization of anti-hnRNP A1-M9 antibodies and isotype control IgG antibodies in the CNS of mice. Following pertussis injection to disrupt the blood brain/spinal cord barrier and injection of near IR-labeled anti-hnRNP A1-M9 antibodies, there is a signal consistent with localization of the antibodies to the brain and spinal cord (a). Under identical conditions, there was a minimal signal using the isotype control IgG (b). Neither antibody localized to CNS structures without pertussis injection (c, d)

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