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Table 1 Differential expression of miRNAs following rituximab therapy

From: Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO)

Upregulated miRNAs Downregulated miRNAs
miRNA treated vs untreated Fold change p value miRNA treated vs untreated Fold change p value
hsa-miR-16 1.99 0.00001 hsa-miR-125b (#^) 0.17 0.00001
hsa-miR-15a 2.65 0.00001 hsa-miR-760 (#^) 0.08 0.00005
hsa-miR-124 6.42 0.00012 hsa-miR-135a (#^) 0.18 0.00058
hsa-miR-26b 1.91 0.00044 hsa-miR-134 (#^) 0.1 0.00183
hsa-miR-7 3.8 0.00085 hsa-miR-138 (#^) 0.18 0.00515
hsa-miR-15b 1.79 0.00206 hsa-miR-423-3p (#) 0.4 0.00734
hsa-miR-451 1.85 0.00233 hsa-miR-100 (#) 0.31 0.00818
hsa-miR-454 2.09 0.00458 hsa-miR-125a 0.24 0.00925
hsa-miR-17 1.66 0.00735 hsa-miR-135b(#^) 0.18 0.01455
hsa-miR-144 2.13 0.01293 hsa-miR-203 (#) 0.2 0.01629
hsa-miR-1180 3.53 0.01837 hsa-miR-660 (#) 0.31 0.04582
hsa-miR-106a 1.71 0.01897 hsa-miR-30d 0.34 0.000002
hsa-miR-184 3.41 0.03243 hsa-miR-200c 0.09 0.00003
hsa-miR-374b 1.62 0.03371 hsa-miR-30a 0.18 0.00003
    hsa-miR-99a 0.1 0.00009
    hsa-miR-29a 0.25 0.00034
    hsa-miR-200b 0.1 0.00043
    hsa-miR-24 0.47 0.00076
    hsa-miR-30e 0.33 0.001
    hsa-miR-27b 0.38 0.00199
    hsa-let-7c 0.44 0.00711
    hsa-miR-375 0.14 0.00836
    hsa-miR-152 0.23 0.01717
    hsa-miR-148b 0.43 0.01862
    hsa-miR-361-5p 0.23 0.01937
    hsa-miR-221 0.46 0.02188
    hsa-miR-200a 0.21 0.02416
    hsa-miR-328 0.4 0.02717
    hsa-miR-92a 0.71 0.02719
    hsa-miR-27a 0.48 0.0307
    hsa-miR-181a 0.49 0.04338
    hsa-miR-143 0.38 0.04993
  1. miRNAs with increased expression in NMO patients that were normalized following rituximab therapy are indicated by (#); brain-specific/enriched miRNAs are marked with (^)