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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study

Fig. 2

Inhibitory effects of ASH-WEX and FIV on LPS-induced inflammatory mediators’ expression in primary microglia. A Representative confocal images of activated primary microglial cells with or without pretreatment with ASH-WEX and FIV immunostained with (a) NFkB and (b) AP1. B i, ii Histograms represent the relative optical intensities of NFkB and AP1, respectively, in different treated groups as compared to control. C i Represents the relative production of the nitrite in different treated groups as compared to control due to neuroinflammation as estimated by the Griess reagent. C ii Representative MMP zymograms for control and different treated groups and histograms represent densitometric analysis of MMP bands. *p < 0.05 represents statistically significant difference between control and LPS + ASH-WEX and LPS + FIV-treated groups. + p < 0.05 represents statistically significant difference between control and LPS-treated group. # p < 0.05 represents statistically significant difference between LPS and LPS + ASH-WEX and LPS + FIV-treated groups

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