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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice

Fig. 2

pIONL induces persistent CXCL13 expression in the TG. a The time course of Cxcl13 mRNA expression in the ipsilateral TG from naïve, sham, and pIONL-operated mice. pIONL increased Cxcl13 expression at 3, 10, and 21 days, compared to sham. *P < 0.05, ***P < 0.001. Two-way ANOVA followed by Bonferroni test. b Western blot shows increased CXCL13 protein level 10 days after pIONL, compared to sham. *P < 0.05. Student’s t test. c Representative images of CXCL13 immunofluorescence in the TG. CXCL13-IR was low in naïve mice (c) and sham mice (d), but increased in the TG of pIONL mice (e). f–h Double staining of CXCL13 (f) and neuronal marker β-III tubulin (g) shows the neuronal expression of CXCL13

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