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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model

Fig. 5

Pneumococci leave the blood vessels after systemic infection. a, b Confocal microscopy images at maximum projection of Tg(kdrl:mcherry) s896 zebrafish embryos injected in the caudal vein (CV) a before formation of the blood-brain barrier (BBB) at 2 days post fertilization (dpf) or b after the formation of the BBB at 4 dpf. Bacteria were localized inside (arrows) and outside (arrow heads) the blood vessels. All embryos were infected with 400 CFU and imaged at 24 h post injection. Scale bars, 50 μm

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