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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia

Fig. 1

Exendin-4 treatment reduced the stroke volume and improved neurological function after cerebral ischemia. a Prothrombin time-international normalized ratio values (PT-INR) in non-MCAO mice after 0, 6, 12, and 24 h of warfarin administration through drinking water. b Regional cerebral blood flow (rCBF) in both ischemic and reperfusion stages was recorded using laser Doppler cerebral blood flow. c Exendin-4 (Ex-4, 10 mg/kg) was injected through the tail vein immediately after reperfusion. The infarct volume was measured 72 h after middle cerebral artery occlusion (MCAO) using TTC straining. d Representative images of TTC straining showing the ischemic area and hemorrhage transformation. e, f Exendin-4 (Ex-4, 10 mg/kg) was injected through tail vein immediately after reperfusion. The neurological deficits were measured 72 h after MCAO, and assessment of motor function was analyzed on days 3 and 7 using rota rod after MCAO. Data are presented as mean ± SD and analyzed by two-way ANOVA. *P < 0.05 compared with the Ex-4(−) group, # P < 0.05 compared with the MCAO+/Ex-4(+) group

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