Fig. 3

Exendin-4 treatment preserved BBB integrity in warfarin-associated HT after cerebral ischemia. Western blot analysis of a, b p-GSK-3β/GSK-3β; c, d p-β-catenin/β-catenin; e, f claudin-3; and g, h claudin-5. Representative blots from six independent experiments with similar results are shown. (Sham: sham-operated group, Ctrl: MCAO group, W: warfarin-associated HT group, W + Ex-4: warfarin-associated HT pretreatment with Ex-4). Data are presented as mean ± SD from six independent experiments and analyzed by one-way ANOVA. *P < 0.05 vs. MCAO group; ^# P < 0.05 compared with warfarin-associated HT group