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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway

Fig. 3

TBEV infection induces RANTES production within the brain of mice. a Expression of 40 inflammatory factors in the mice brain detected by an inflammation Ab array assay. Representative photomicrographs demonstrate that TBEV infection stimulated RANTES (indicated by arrows) expression. Data shown are pooled from three independent experiments (n = 4 mice per group). b Time course of TBEV-induced stimulation of RANTES protein expression in different tissues. Bars represent the means ± the standard deviations of three independent experiments (n = 4 mice per group). The fold changes in expression of RANTES in the brain of TBEV-infected mice were significantly higher when compared to those of the peripheral tissues and sera on days 3, 4, 5, and 8 p.i. (* P < 0.05). c Fold changes of RANTES protein levels in the brain and serum of TBEV-infected adult mice. Bars represent the means ± the standard deviations of three independent experiments (n = 4 mice per group). The fold changes in expression of RANTES in the brain of TBEV-infected mice were significantly higher when compared to that of the sera on days 5, 8, and 11 p.i. (* P < 0.05)

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