Fig. 4

Large-scale lipid screening in the cerebellum (CBL) and the cortex (CTX) at week 16. Phospholipids, lysophospholipids, ceramides, sphingomyelins, N-acylethanolamines, dihydroceramides, and sulfatides were measured in the cortex and cerebellum of CTL and HFD mice at week 16 by HPLC-MS. The color red represents an increase in lipid levels in the HFD mice compared with the CTL mice. The color green represents a decrease in lipid levels in the HFD mice compared with the CTL mice. Numerical data are reported in Additional file 1: Table S2-4. ND not detected. For phospholipids, the sum of R1 and R2 acyl chains are indicated, whereas for the other lipids the R acyl chain is mentioned