Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

Fig. 4

HMGB1 increases BBB permeability to dextrans of various sizes. HCMEC/D3 cells in the transwells were incubated with HMGB1 (5, 10, or 50 ng/ml) for 3 h and the apical to basal flux of a mixture of florescent-labeled dextrans of different sizes (FITC-4 kDa; Cascade Blue 10 kDa; and RITC-70 kDa) was assayed following 30 min after the addition of dextrans. (*p < 0.05 vs. control and N = 5/condition)

Back to article page