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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

Fig. 1

Fractionated whole-brain irradiation causes persistent hippocampal-dependent memory deficits. a Schematic charts of experiment timeline and cognition tests paradigm. Fractionated irradiation was delivered at 3.3 Gy/day every other day; NOR test was performed 4 and 13 weeks after the last radiation fraction; DMP tests were performed at 5 and 12 weeks after fWBI; matrix distance test was performed 8 weeks after fWBI. b Analysis of NOR at 4 weeks after fWBI (day 4 of NOR test, ****p < 0.0001, ns = not significant, n = 17, t test). c Discrimination index analysis for the NOR task (**p < 0.01, n = 17, t test). d Results of NOR at 13 weeks after fWBI (****p < 0.0001, ns = not significant, n = 7–8, t test). e Discrimination index analysis for the NOR test at 13 weeks post fWBI (***p < 0.001, n = 7–8, t test). f DMP test showed no impairment in working memory after fWBI (n = 7–8, two-way ANOVA). g Matrix distance test day 1, animals in the sham group but not in the irradiated group had significantly increased exploring time in trial 3 compared to trial 1 (**p < 0.01, n = 7–8, two-way ANOVA). (h) Matrix distance test day 2, only the animals in the sham group had significantly increased exploring compared to trial 1 (*p < 0.05, n = 7–8, two-way ANOVA)

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