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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

Fig. 2

CSF-1R blockade prevents memory deficits and loss of dendritic spines after fractionated irradiation. a Schematic chart of experiment design. Mice were treated with PLX5622 7 days before the first radiation fraction and continued for a total of 21 days. NOR test was performed 4 weeks after the last radiation fraction. Mice were euthanized 1–2 days after the NOR test for Golgi staining. b Analysis of percentage time spent in exploring each object on test day (***p < 0.001, ****p < 0.0001, n = 11–12, t test). c Discrimination index analysis for the NOR task (*p < 0.05, ns = not significant, compared to control sham; FPLX5622 = 13.99, p = 0.0005; FIRR = 5.825, p = 0.0201; FInteraction = 3.198, p = 0.0808; n = 11–12, two-way ANOVA). d Representative images of dendrites from Dentate Gyrus granule neurons (×100, scale bar = 10 μm). e Comparison of dendritic spine densities (*p < 0.05, **p < 0.01, ****p < 0.0001, ns = not significant; FPLX5622 = 14.69, p = 0.0012; FIRR = 1.287, p = 0.2715; FInteraction = 29.81, p < 0.0001; n = 6, two-way ANOVA)

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