Fig. 4

Chronic social defeat produces disrupted social scores in mice lacking CCR2+ monocytes. a Binary images of urine scent marks from Ccr2 ^wt/wt mice and mice lacking CCR2-containing monocytes (Ccr2 ^rfp/rfp) exposed to homecage (HC) or chronic defeat stress (SD). b Defeated groups showed a sharp reduction in scent marking compared to HC groups; absence of CCR2-positive monocytes did not confer resilience to social defeat. c Heat maps illustrating the effects of social defeat on social behavior during the social interaction test. d Chronic SD mice spent significantly less time with the aggressor mouse in the social interaction test compared to non-stressed control mice; depressive-like behavior was comparable between genotypes. Ms mouse, Obj object. Results are expressed as mean ± SEM (n = 8 per group). One-way ANOVA followed by Bonferroni’s post hoc test **p < 0.01, ***p < 0.001