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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Fig. 8

Microglial phagocytic activity is enhanced by chronic social defeat. a Representative examples of phagocytosis of neuronal debris are shown. Microglia from homecage (HC) and acute (ASD) or chronic social defeat (CSD) were incubated for 3 h with fluorescently labeled ultraviolet-irradiated neural cells and stained with anti-CD11b. Confirmation of phagocytosis is provided in orthogonal projections of confocal z-stacks shown in the HC picture. Scale bar = 20 μm. b Bar graphs compare surface area of ultraviolet-irradiated neural cells (NC) to total surface area (mean ± s.e.m.) of HC, ASD, and CSD microglia (**P < 0.001; one-way ANOVA; representative experiment shown out of three independently performed)

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